Keep an eye on Carefully (3)pentobarbital will minimize the level or effect of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Powerful or moderate CYP3A4 inducers may increase charge of diazepam elimination; for that reason, efficacy of diazepam may very well be decreased.pentobarbital will decrease… Read More